Activation of aryl hydrocarbon receptor (AhR) by environmental pollutants such as Dioxins or PCBs leads to altered expression of key factors critical for the function of Dendritic cells (DCs). The AhR can modify the process of maturation of DCs/Macs, which is important in understanding the development of the different types and subsets of DCs. This project is focusing on the mechanistic understanding of how the activity of AhR may modify the differentiation and function of DCs. Compounds like dioxins/PCBs or other persistent organic pollutants, which activate the AhR will affect the immunogenicity of DCs and the immune response. These mechanisms could possibly represent the reason for the increasing incidence of allergies and autoimmune diseases caused by exposure to environmental pollutants.
Last updated: March 05, 2014
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